It helps cells generate energy and purifies metabolic waste products called free radicals. If you don’t already know it, alpha-lipoid acid is a fatty acid you’re going to want to learn more about. However, there is little research exploring the long-term safety of alpha-lipoic acid, including at what point the supplement may become toxic. dose of lipoic acid. Alpha-lipoic acid given at 600 mg b.i.d. Spence and McCormick tested only labeled i.p. Lipoic acid is unique among other antioxidants because it is both water-and fat-soluble.. You get small amounts of lipoic acid in your diet from spinach and collard greens, broccoli, beef and organ meats.. 2 It also promotes healthy function of mitochondria, your cells’ energy generators. The Amazing Alpha-Lipoic Acid. In general, i.p. These medications are not usually taken together. Acid Blockers and Antacids Example drugs that can deplete B vitamins* Proton Pump Inhibitors, Ranitidine, Cimetidine, Esomeprazole, Famotidine, Lansoprazole, Omeprazole, Aluminum and Magnesium Antacids. Alpha-lipoic acid or ALA is a naturally occurring compound that's made in the body. Even if such a reduction occurred the relevance to humans is not clear. Alpha-lipoic acid is an antioxidant also known as Acetate Replacing Factor, ALA, Biletan, Lipoicin, Thioctan, and many other names. However, you would have to consume a lot of raw eggs for that to happen - two or more a day for several months. Alpha Lipoic Acid Summary. Therefore plasma levels of the test substance after i.p. J Nutr (1997) Sep;127(9):1776-81. Experts recommend supplementing with 2-4 mg/day of biotin if you're taking alpha lipoic acid for conditions such as high blood pressure. Even scientists are guilty of over extrapolating the results of this study. Lipoic acid a multi-level molecular inhibitor of tumorigenesis, Effects of Alpha Lipoic Acid in Obese Children and Adolescents, Lipoic Acid a Multi-Level Molecular Inhibitor of Tumorigenesis, R-Lipoic Acid is the eutomer of Lipoic Acid, Competitively inhibits biotin uptake & transport or, Displaces biotin from the holocarboxylase synthetase enzyme or. Biotin is critical, because without it, chronic use of lipoic acid will eventually lead to hair loss. Alternatively, Zempleni et al might have been correct about the long t ½ which could be unique to their dosage form and route of administration but due to the reasons cited above would not apply to orally consumed lipoic acid by humans. Contrary to this suggestion, high doses of biotin are known to down-regulate (reduce the number of enzymes encoded by DNA and translated into protein) the holocarboxylase, whereas low doses induce up-regulation (increase the number of enzymes encoded by DNA and translated into protein) in order to effectively bind miniscule amounts of available biotin.10 Possibly, simultaneous presence of both prevents normal down regulation. Zum Wunschzettel hinzufügen. This product is not intended to diagnose, treat, cure or prevent any disease. The write up on the first brand said if you are taking Lipoic acid regularly, it can deplete biotin so biotin is included. injections of the salts of lipoic acid produce faster and higher plasma and tissue concentrations than per oral (p.o) doses and the elimination ½ live (t ½) is longer. lipoic acid-treated rats were less than in controls (the activity was 64-72% of control values). If you were reading this blog the other week, you may have seen my post about “The Seven Super Supplements.” Of those, one I’d like to take a moment to talk more about is alpha-lipoic acid (ALA). Taking ALA daily at doses of 1800mg for 20 weeks can help in the reduction of weight. injection of test articles dispersed in PC/saline) as well as a suspected reporting error in lipoic acid PK data (incorrect elimination ½ live or t ½ [explained below]), utilized “heroic” doses of biotin and thus made conclusions that have been erroneously extrapolated to normal human lipoic acid consumers by scientists, doctors and nutritional supplement companies. Zempleni et al used rac-lipoic acid so it is unknown if the single enantiomers of lipoic acid (R-lipoic and S-lipoic acid) would cause similar reductions in the carboxylase activities even under identical experimental conditions. This appears to be irreconcilable with the reported plasma t ½ of 51.9 hrs and 60.6 hrs. doses but not the i.p. So a chronic use of lipoic acid which I personally think is a marvelous idea if you want to live longer (and help control hair loss) will deplete stores of biotin to the point of hurting hair. Eosinophila are a type of white blood cell typically released by the immune system in the present of an allergen, virus, or bacteria.. While the i.p. In people with genetic disorders that cause biotin deficiency, doses as high as 200 mg/day have been given without adverse side effects. Biotin is added for optimum alpha lipoic acid activity. I call this issue the “lipoic acid–biotin mandate”. It can actually be found in every cell in the body, as it’s needed to … and p.o. If you require any medical related advice, contact your physician promptly. “However the pathological implications of such a decrease are not clear. Tissue levels return to baseline within 24 hours. A decrease in PGC1α impairs mitochondrial function which increases oxidative stress and depletes glutathione. Alpha-lipoic acid is effective in prevention and treatment of experimental autoimmune encephalomyelitis. In the high dose group lipoic acid: biotin was administered in a molar ratio of 7.8:1 and co-administration of biotin prevented the reduction in carboxylase activities. Morini M, Roccatagliata L, Dell'Eva R, et al. Alpha lipoic acid (ALA) is produced in small amounts by humans, and thus is not a true vitamin. Alpha lipoic acid is a unique lipid and water soluble antioxidant that is a cofactor in energy production, helping to regulate glucose metabolism. J Nutr Biochem. The exact mechanism for lipoic acid as a treatment for MS is unknown, and the results of studies are mixed. 2002;131(1-2):104-114. These drugs, along with valproic acid, also reduce absorption of folate from foods. Artikel-Nr. Ever meet those people who look like they wrestled time to a standstill? dose used by Zempleni et al. Produktdetails . I plan to send my critical analysis of the study to the authors and the Journal of Nutrition (which published the initial study) for comment. These include:1, 73, Similar pharmaceutical compounds may cause the same side effect (e.g., Trileptal®).1, However, clinical studies show that biotin supplementation can counteract these biotin-depleting side effects.1, 73, The avidin in raw egg white binds to biotin and can block its absorption from the intestines and cause biotin deficiency. Alpha-lipoic acid is an antioxidant produced naturally in the body. Alpha lipoic acid also promotes the synthesis of glutathione. Amazing supplement may help freeze the aging process. They only analyzed the radio-labeled content of plasma and tissues at two later time points (4 hr and 24 hr) which precludes the possibility of determining the concentration versus time curve. 2-Regular users of lipoic acid products MIGHT benefit from supplemental d-biotin or d,l-biotin but it is probably wiser to consume biotin at a different time than lipoic acid to insure optimal absorption of both nutrients. lipoic acid. Long-term, high-dosage biotin supplementation (5 mg/day for two years) has been reported as well-tolerated with no toxicities.5. Surprisingly, Zempleni et al did NOT recommend supplemental biotin either for people with or without carboxylase deficiencies. We sought to determine whether the chronic administration of lipoic acid affects the activities of biotin-dependent carboxylases. Alpha lipoic acid or lipoic acid is one of the substances that protect the body from free radical-producing molecules. Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential. Zempleni et al state that the pharmacokinetics of lipoic acid was “independent of the route of administration” which was based on the findings of two earlier studies which were apparently conflated. Alpha-lipoic acid is found in many foods in small amounts. injection do not correlate well to tissue levels of the same compound consumed orally. A therapeutic dose of 600 mg lipoic acid would require ~91.3 mg biotin. ALA is a potent antioxidant and regenerates other antioxidants. 300-600 for improvement. Krone compared the PK directly of i.p., intravenous (i.v.) I’ve personally been using Lipoic acid for several years, in fact the stronger kind stabilized R-Lipoic acid. 7. Everything … When the vitamin usage was stopped the patient's condition improved. Insufficient biotin creates an environment where an aggressive form of the yeast Candida can take root, penetrating the intestinal wall and spreading into the bloodstream.72, Certain anticonvulsant medications used to treat epilepsy have been shown to reduce levels of biotin in the blood. This has been overlooked by other lipoic acid researchers and ALL of the companies advocating the “lipoic acid-biotin mandate” relying on Zempleni et al as definitive. Alpha-lipoic acid is a fatty acid made by your body. The authors used a rat model that is not readily extrapolated to humans, based their conclusions on a reporting error in lipoic acid pharmacokinetic (PK) data and did not take into consideration the differences in dosage forms, routes of administration and the differences between lipoic acid and biotin PK in rats and humans. Having too much of this amino acid floating around in your bloodstream can cost you a few IQ points! Therefore the results of this study may have less to do with the dose of lipoic acid used and more to do with how it was dispersed. Since Homocysteine = bad; S-adenosylmethionine (SAM) = good, as a result of this paper it might pay dividends for life extensionists to consider whether or not it is worth dropping ALA supplementation levels somewhat and increasing … Cell and molecular aspects of human intestinal biotin absorption. Alpha-lipoic acid is produced in small amounts in the mitochondria, which, you may remember from science class, is the “powerhouse” of a cell. The i.p. How Does Alpha Lipoic Acid (ALA) Work? It’s found primarily in organ meat and some vegetables, although in small amounts. Below is a highlight of my reasons for removing d-biotin from our products as well as the Zempleni et al study, findings, conclusions and my critical analysis. 900mg if really bad. lipoic acid of 51.9 hrs and that of i.v. © Copyright 2020 - Dr. Christianne Schelling - Aquanta LLC - All Rights Reserved, genetic disorders that cause biotin deficiency. I suggest the difference in tissue concentrations between the low and high doses of lipoic acid rather than the “allegedly” long t ½ of lipoic acid accounts for the findings of this study. Alpha-Lipoic Acid with Biotin. Arzneimittelforschung. Legal Disclaimer *These statements have not been evaluated by the Food and Drug Administration. 2000 Jul;3(4):263-6. to relapsing-remitting MS patients was barely measurable in serum; but alpha-lipoic acid given at 1200 mg once daily showed much higher serum levels. Zempleni et al relied on PK data provided by Peter & Borbe who reported the t ½ for p.o. Cooked egg white does not present a problem since heat denatures avidin and prevents the binding mechanism.1, Biotin enhances the effectiveness of some nutrients, such as pantothenic acid. In the discussion section of the lipoic acid-biotin study as well as in a subsequent review article11 Zempleni backed off of the strong warnings concerning the possible relevance of the study to human lipoic acid users with carboxylase deficiencies. 1995 Mar;45(3):293-9. dose was 5.58 hrs. dose] a 70 kg human lipoic acid user consuming 225.3 mg/ lipoic acid/day (equivalent to the rat high dose) would need to consume 34.3 mg biotin/day or 1141 times greater than the amount considered to be the adequate intake (AI=~30 ug/day). Your body does in fact manufacture Alpha-Lipoic Acid, but supplementing it provides benefits beyond its involvement in carbohydrate metabolism. Higher alpha-lipoic acid serum levels was associated with lower MMP-9 levels and lower soluble intercellular adhesion molecule 1 (ICAM-1) levels. “The great bioavailability of i.p. does used by humans. Alpha-lipoic acid may be anti-aging wonder supplement . It plays a key role in metabolism and energy production. Alpha-lipoic acid is a natural antioxidant that provides benefits for the liver, nerves and protects against oxidation. The mechanisms by which ALA exerts its effects include protection against oxidative stress-induced IR, inhibition of hepatic gluconeogenesis, and increased peripheral glucose use. Endogenously synthesized lipoic acid is bound to protein and functions as a cofactor for several important mitochondrial multienzyme complexes. Alpha-Liponsäure ist ein natürliches Antioxidans, das für Leber und Nerven vorteilhaft ist und gegen Oxidation schützt. J Nutr. Zempleni J, Mock DM. Produktdetails Zusammensetzung Zubehör Bewertungen. As a point of reference, the average human diet provides 35-70 ug/day.10. I assume the addition of 85.6 ug/day i.p. Alpha lipoic acid is a naturally-occuring fatty acid. Oxygen Club of California PowerPoint presentation by March 15, 2008. In other words, tissue concentrations could be much higher than what is reflected in the plasma and this could cause the reduction in the activities of the biotin dependent enzymes. Migraine headache. But lipoic acid declines in your body as you age. This article is frequently cited and is the first reference to appear on the lipoic acid page on encyclopedia.com. Early research suggests that taking 600 mg of alpha-lipoic acid daily for 3 months improves the severity and frequency of migraines. Alpha-lipoic acid may play a role in weight loss. J Neuroimmunol. This is a fascinating proposal with health implications and should be studied further. The test compounds were all administered as PC dispersions in saline. In MS, damage to the myelin sheath, theprotective layer that surrounds nerve fibers, disrupts the transmission of nerve signals. injections of each of the following for 28 days; a control group receiving i.p injection of a phosphatidyl choline (PC) dispersion in saline, a low dose lipoic acid group; a high dose lipoic acid group, a high dose lipoic acid + biotin, and a group receiving hexanoic acid (a structural analog of lipoic acid). lipoic acid maintained the normal activities of the carboxylase enzymes. Interestingly, Peter and Borbe reported 78 and 84% of labeled lipoic acid was recovered in the 24 hr urine from the p.o. 1999 Jun 1;366(1):95-106. dose did NOT. Alpha lipoic acid benefits include supporting glucose metabloism, and this is perhaps it's best known feature. Due to PK differences between p.o. In contrast to the findings of Zempleni et al the in vitro study and experimental conditions used by Wiener & Wolf may be more relevant than those used by Zempleni et al since the short incubation times used in their study (3-24 hrs) more closely mirrors the plasma and urinary elimination kinetics of lipoic acid in humans. It is one of the safest ALA supplements today. route of administration used in rats and the p.o. follijinxed – Lipoic acid (or alpha lipoic acid) “uses up” biotin. above the amount obtained in the daily diet (average daily p.o. I was unable to find any other studies (animal or PK) using this method of dispersing the test compounds and so it is impossible to state what effect this would have on subsequent plasma or tissue levels. Johann Wolfgang Goethe University, Frankfurt am Main, Germany; 2002. 33,79 € SUPER SALE 30,41 € speichern 10% In den Warenkorb. Note this is still 10 fold lower than the results reported by Peter & Borbe and relied upon by Zempleni et al to reach their conclusions. intake=26 nmol/day=6.35 ug/day) causes either sufficient tissue saturation or high tissue levels for a long enough period of time that it successfully competes with lipoic acid since as we have shown all lipoic acid PK studies indicate a short rather than long t ½. administration of lipoic acid and supplemental biotin was used in a rat model and the results were extrapolated to humans who consume lipoic acid and biotin orally without consideration of the pharmacokinetic differences between the two species or the routes of administration. One of the main benefits of taking alpha-lipoic acid is the weight loss tendency it has. © Copyright 2013 GeroNova Research, Inc. All Rights Reserved | Policies. Curr Opin Clin Nutr Metab Care. The questionable methodology and conclusions of this study raise questions concerning its relevance to humans and until now has not been critically examined. These cells move into the brain and spinal cord and begin to target myelin, leading to an inflammatory response. It also works by restoring the level of vitamins in your body, such as Vitamins C and E. There are also pieces of evidence showing that the alpha lipoic acid neuropathy may help to improve the function of neurons for diabetes. The mechanisms by which ALA exerts its effects include protection against oxidative stress-induced IR, inhibition of hepatic gluconeogenesis, and increased peripheral glucose use. My list adds up to a bazillion people! This occurs despite the fact that both B vitamins are broken down and absorbed along the same metabolic pathways.65, 74, There has been one report (from 2001) of a serious health problem that occurred in a woman who took the combination 10 mg biotin and 300 mg/day of pantothenic acid (vitamin B5) daily for two months. Your body does in fact manufacture Alpha-Lipoic Acid, but supplementing it provides benefits beyond its involvement in carbohydrate metabolism. ( iv .88 ) Results of clinical trials using higher doses of alpha lipoic acid have shown benefit in patients who already have … Carlson DA, Smith AR, Fischer SJ, Young KL.A comparison of the pharmacokinetic profiles of lipoate enantiomers with the racemic mixture in healthy human subjects indicates possible stereoselective gut transport. There have, in fact, been several reports of seizures and vomiting in children who have taken doses of 2,400 mg or greater. My list adds up to a bazillion people! Alpha-lipoic acid is an organic compound that acts as a powerful antioxidant in your body. Krone concluded rat PK (particularly the i.p. I suggest the results of this study were due to unique problems associated with the study design or to PK differences between PC/saline and salt dosage forms of lipoic acid as well as the differences between the i.p. Severe Interactions. Alpha lipoic acid (ALA) is a potent antioxidant that is considered important for the treatment of metabolic syndrome. Directions. There is no evidence the results of this study indicate lipoic acid poses any adverse health implications for humans with or without carboxylase deficiencies. 3- The study being utilized to justify the “lipoic acid-biotin mandate” was done by two respected and frequently published biotin researchers (Zempleni & Mock; the third, Trusty is not as well known). so getting in those greens is important. lipoic acid 60.6 hrs.6-8 This caused Zempleni et al to conclude that chronic administration and the long t ½ for lipoic acid would overlap the turnover times for the carboxylase enzymes and prevent new biotin from binding to the intermediate holocarboxylase synthetase enzyme (the enzyme responsible for transferring free biotin to the apocarboxylase enzymes) or from biotin from becoming incorporated into the apocarboxylase enzymes (the carboxylase enzymes without the biotin substrates) due to possible competition with lipoic acid due to structural similarities between the two molecules. There are no reports of toxicity from biotin, and oral supplementation is well-tolerated at even very high doses. It is unlikely to cause biotin deficiency, however, since studies show bacteria only contributes about 20% of biotin in the body.1, 69-71, While antibiotic reduction in bacteria like acidophilus and bifidobacteria may not result in biotin deficiency, prolonged lower levels of biotin in the intestines suppresses the immune system. That said, I’ve been taking copious amounts of Biotin everyday. If you don’t already know it, alpha-lipoid acid is a fatty acid you’re going to want to learn more about. It has been demonstrated by several groups of researchers (including Zempleni et al) in this and other studies that lipoic acid, biotin and pantothenic acid utilize at least one of the same transport systems and co-administration results in competition for uptake in various model systems. doses of biotin compensate for the high tissue concentrations of lipoic acid resulting from i.p. It is also important to point out that an earlier study by Weiner & Wolf 5 whose model more correctly mirrored lipoic acid PK in humans found contradictory results; i.e. Alpha-lipoic acid, sometimes referred to as ALA, is an antioxidant produced in small amounts by the body 3 7. Alpha lipoic acid (ALA) is produced in small amounts by humans, and thus is not a true vitamin. Also known as thioctic acid, ALA is naturally produced in the body, as well as absorbed from certain foods we eat, such as red meat, spinach, potatoes, broccoli, yams, carrots, beets and yeast [source: American Cancer Society]. Alpha lipoic acid is also known as lipoic acid and thioctic acid, but whatever you choose to call it, it remains a compound found in almost every cell in your body – providing protection to those cells. Anti-Inflammatories Drugs that can deplete B vitamins* Non-Steroidal Anti-Inflammatories (Ibuprofen, naproxen), Corticosteroids (hyrdocortisone, fluticasone) Information presented on this website is exclusively of a general reference nature. These include kidneys, spinach, liver, broccoli, heart tissue, and tomatoes. 147 ALA may also exert modest reductions in plasma nonesterified fatty acid concentrations. Alpha-lipoic acid is a naturally occurring fatty acid that can be found in many foods such as yeast, spinach, broccoli, potatoes, and organ meats such as liver or kidney. The B vitamins and selenium are easy to get in a well-rounded, whole food diet that does not eschew animal products as meats are the best sources of selenium and multiple vitamins in the B family. Supplementation with lipoic acid transiently increases plasma and cellular concentratio… Page 1 of 2 - Alpha Lipoic Acid causes massive S-adenosylmethionine (SAM) depletion - posted in Supplements: Another worrying ALA rat study is set out below. Biochemical Medicine and Metabolic Biology, Volume 46, Issue 3, December 1991, Pages 344-363. B) Non-validated Route of Administration: Intraperitoneal (i.p.) Of those, one I’d like to take a moment to talk more about is alpha-lipoic acid (ALA). Yeast depletes B6, CoQ10, alpha lipoic acid and biotin. When I spoke to my doc she said I was probably low on Biotin, and to take 2 to 4 mg daily. 24% of those users who reviewed Alpha-lipoic acid reported a positive effect, while 28% reported a negative effect. The rats all received an experimental diet, ad libitum (they ate freely as much as they wanted), containing 1.27 umol (0.31 mg) biotin but without supplemental lipoic acid. Carlson DA. and p.o. Let’s look at why these vitamins, and their depletion, are important for development: Vitamin B6 is blocked when aldehydes from yeast bind to proteins. It can also be obtained from healthy foods like spinach, broccoli and beets. Does Biotin-Alpha Lipoic A-Min-Hb91 Tablet Interact with other Medications? It also really depends on your intended use. Alpha-lipoic acid induces elevated S-adenosylhomocysteine and depletes S-adenosylmethionine. How then do researchers inject it? Antacid B Vitamin Depletion but these results likely will be found with chronic oral administration.” As discussed above this conclusion is not likely correct. Briefly, Zempleni et al found the activities of pyruvate carboxylase and B-methyl-crotonyl-CoA carboxylase (2 of 4 biotin dependent enzymes) in livers from the high dose, i.p. Posted: December 14, 2013. Here are 8 little known benefits of alpha lipoic acid (ALA): 1. Elford HL, Wright LE. Alpha-lipoic acid is an organic compound that acts as a powerful antioxidant in your body. Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer’s Disease? 300-600 for improvement. Therefore p.o. If you’re taking other supplements with biotin, be aware that both alpha-lipoic acid and vitamin B5 (pantothenic acid) can work against the absorption of biotin. These include: Since both biotin and alpha lipoic acid are absorbed and metabolized in the body along the same pathways, long term use of alpha lipoic acid could result in low biotin levels. Stabler SP, Sekhar J, Allen RH, O'Neill HC, White CW. Experts recommend supplementing with 2-4 mg/day of biotin if you're taking alpha lipoic acid for conditions such as high blood pressure.65, 68, Long-term use of antibiotics (such as tetracycline and sulfa) can reduce biotin levels. and i.v. User Reviews for Alpha-lipoic acid to treat Dietary Supplementation. Since biotin is cheap and might be beneficial, why don’t you recommend people take it with lipoic acid? Let’s see how Zempleni et al and the J of Nutrition respond to my critique. View the poster from OCC Santa Barbara, CA March 12-15, 2008. https://geronova.com/docs/Comparison_PK_poster.pdf. 88. The justification of using the racemate in the present study by claiming d and l-lipoic acid (d-LA= (+)-LA=RLA and l-LA= (-)-LA=SLA) were similarly catabolized by microorganisms is misplaced, since rats and humans are NOT microorganisms and catabolism of lipoic acid was not shown in this study to have any influence on the results or conclusions.
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